VietnamPartner Site

Site project · Hepatitis C

DRIVE-C

Towards HCV elimination among people who inject drugs

Project overview

Evaluation of an integrated community-based model combining hepatitis C screening, simplified treatment and peer support in Hai Phong.

Objective

Assess the effectiveness of an integrated hepatitis C screening and care model for people who inject drugs, including its durability 36 months after treatment initiation.

Study design

Participants were recruited through the DRIVE respondent-driven sampling surveys and cohort. The model combined mass community screening, simplified direct-acting antiviral treatment and community support for referral, retention, adherence and reinfection prevention. Ancillary studies examined mitochondrial genotoxicity, occult hepatitis and telomere length.

Consortium

Project leadership and partner institutions

Principal investigators

  • Pham Minh KhueHai Phong University of Medicine and Pharmacy
  • Didier LaureillardNîmes University Hospital / UMR 1058

Partner institutions

  • UMR 1058, Montpellier
  • Hai Phong University of Medicine and Pharmacy
  • New York University
  • SCDI
  • Hai Phong CDC
  • Viet Tiep Hospital

Scientific production

Publications and communications

View the full bibliography →

  1. Trickey A, Walker JG, Khue PM, Hong TT, Binh NT, Quillet C, Vallo R, Bivegete S, Oanh KTH, Fraser H, Huong DT, Pollack T, Nhung VTT, Jarlais DD, Vinh VH, Nagot N, Laureillard D, Stone J, Vickerman P. Impact and cost-effectiveness of interventions to eliminate hepatitis C virus among people who inject drugs in Haiphong, Vietnam. International Journal of Drug Policy. 2025;143:104898. doi: 10.1016/j.drugpo.2025.104898.

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  2. Laureillard D, Binh NT, Vinh VH, Hong TT, Quillet C, Thanh NTT, Vallo R, Quynh BTN, Moles JP, Oanh KTH, Huong DT, Rapoud D, Feelemyer J, Michel L, Vickerman P, Fraser H, Weiss L, Lemoine M, Lacombe K, Jarlais DD, Khue PM, Nagot N. High efficiency and safety of hepatitis C treatment among people who inject drugs in Vietnam. Journal of Viral Hepatitis. 2025;32(11):e70090. doi: 10.1111/jvh.70090.

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  3. Nguyen Thanh Binh, Vu Hai Vinh, Tran Thi Hong, Duong Thi Huong, Nham Thi Tuyet Thanh, Delphine Rapoud, Catherine Quillet, Jean-Pierre Moles, Roselyne Vallo, Khuat Thi Hai Oanh, Don Des Jarlais, Didier Laureillard, Nicolas Nagot, Pham Minh Khue and DRIVE/DRIVE-C team. Prevalence and several factors related to HCV infection among people who currently inject drugs in Hai Phong. Vietnam Journal of Preventive Medicine. 2025;35(2 Suppl.):142–150. doi: 10.51403/0868-2836/2025/2362.

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  4. Nguyen Thanh Binh, Vu Hai Vinh, Tran Thi Hong, Cap Minh Duc, Didier Laureillard, Jean Pierre Molès, Nicolas Nagot, Catherine Quillet, Delphine Rapoud, Roselyne Vallo, Khuat Thi Hai Oanh, Nham Thi Tuyet Thanh, Pham Minh Khue and DRIVE-C team. Outcomes of community-based integrated hepatitis C care for people who inject drugs in Haiphong, during 2018–2020. Vietnam Journal of Preventive Medicine. 2025;35(2 Suppl.):113–141. doi: 10.51403/0868-2836/2025/2361.

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  5. Nagot N, Binh NT, Hong TT, et al. A community-based strategy to eliminate hepatitis C among people who inject drugs in Vietnam. The Lancet Regional Health – Western Pacific. 2023;37:100801. doi: 10.1016/j.lanwpc.2023.100801.

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  6. Nhu QBT, Thuy LLT, Nguyen HT, et al. HCV RNA quantification by a domestic commercial assay: a case study among people who inject drugs in Vietnam. Diagnostics. 2023;13(22):3456. doi: 10.3390/diagnostics13223456.

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  7. Nguyen Thanh Binh, Vu Hai Vinh, Nguyen Duc Duong, Tran Thi Hong, et al. Treatment adherence for hepatitis C and related factors in integrated community-based care for injecting drug users in Hai Phong. Vietnam Journal of Preventive Medicine. 2023;33(1 Suppl.):206–213. doi: 10.51403/0868-2836/2023/991.

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  8. Durand M, Nagot N, Nhu QBT, et al. Long-term persistence of mitochondrial DNA instability among HCV-cured people who inject drugs. Biomedicines. 2022;10(10):2541. doi: 10.3390/biomedicines10102541.

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  9. Durand M, Nagot N, Michel L, et al. Mental disorders are associated with leukocyte telomere shortening among people who inject drugs. Frontiers in Psychiatry. 2022;13:846844. doi: 10.3389/fpsyt.2022.846844.

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  10. Durand M, Nagot N, Nhu QBT, et al. Mitochondrial genotoxicity of hepatitis C treatment among people who inject drugs. Journal of Clinical Medicine. 2021;10(21):4824.

  11. Rapoud D, Quillet C, Pham Minh K, et al.; DRIVE-C Study Group. Towards HCV elimination among people who inject drugs in Hai Phong, Vietnam: study protocol for an effectiveness-implementation trial evaluating an integrated model of HCV care. BMJ Open. 2020;10(11):e039234.