Principal investigators
- Patrick SoussanInserm U1135 – CIMI, Paris
- Van Tu DaoNational Cancer Hospital, Hanoi
Site project · Hepatitis B
HBV-related HCC
HBV expression and the tumour immune microenvironment
Project overview
A translational study of how hepatitis B virus expression shapes the immune microenvironment of resected hepatocellular carcinoma in Vietnamese patients.
Objective
Evaluate the impact of intratumoral and peritumoral HBV expression—particularly spliced HBV RNA coding for HBSP—on the tumour immune microenvironment and immune infiltrate.
Study design
Prospective cohort of 135 patients undergoing liver-cancer resection at K Hospital, divided into HBV-only, alcohol-only and HBV-plus-alcohol groups. Analyses include RT-qPCR, spectral flow cytometry, multiparametric immunofluorescence, bulk and spatial transcriptomics, and Immunoscore® assessment.
Consortium
Project leadership and partner institutions
Partner institutions
- Inserm U1135 – CIMI
- National Cancer Hospital, Hanoi
- Inserm UMRS 1138